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The cell cycle regulator p21 was cleaved by caspase 3 during zinc deficiency, activating cyclin-dependent kinase 2 (CDK2)

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doi: 10.1105/tpc.106.043125

One notable change is the accumulation of CD8 + T cells that express senescence markers such as CD57 and the T-cell immunoreceptor with Ig and ITIM domains (TIGIT) [311]

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The library comprised 10,480 electrophilic compounds with diverse warheads that target cysteines (for example, acrylamides and chloroacetamides) or other nucleophilic residues (for example, aldehydes and boronic acids) (Extended Data Fig