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However, etorphine, [Leu 5 ]- and [Met 5 ]-enkephalins rather promote a recycling of hDOR while DPDPE, Deltorphin I or SNC-80 induce a degradation and a down-regulation (Marie et al., 2008): when the receptor is phosphorylated by GRK2 and internalized via arrestins it can recycle whereas in a non-phosphorylated form DOR undergoes an arrestin-independent sequestration which is followed by a degradation

Note that the only significant deviation of GSH in Panel B of Figure 2 occurs during days 10-14 when estradiol and S become very high, thus depressing the GSH concentration [Table 1]

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References: Regulation of glutathione synthesis

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