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A failure of homocysteine or MMA to normalize during the first week suggests an incorrect diagnosis, unless renal failure or other causes of metabolite elevation coexist

The recommended dose is one to two tablets every 4 to 6 hours

Along the same line, depleting endogenous GSH with BSO had a worsening effect in some of the models above, including chemically induced pulmonary edema, 21 cigarette smoke, 31 carrageenan-induced pleurisy, 32 and endotoxin-induced pulmonary inflammation

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In most cases, consistent room-temperature storage is preferable to repeated temperature changes, especially if the bottle is being taken in and out of the fridge