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This underscores the highly regulated nature of necrotic cell death (Dovey et al., 2018

As a ligand of the aryl hydrocarbon receptor, IAA can regulate intestinal homeostasis and suppress inflammatory responses

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While this is protective against age-related hyperfunction, it theoretically risks blunting the anabolic responses required for new synaptic formation, muscle hypertrophy, or exercise adaptation in subjects who are not already biologically aged