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doi: 10.1091/mbc.e07-12-1257

10.1007/s11064-024-04163-3 151 ZilleM.KaruppagounderS

Interpreting limits of past ULT trials A guiding doctrine of the ACP guideline was that retrospective studies and even RCTs that used the decline in serum urate level to a pre-stipulated target as an indirect, surrogate outcome, rather than demonstrating the improvement in a clinical outcome such as reduction in frequency of acute gout flares during the randomized phase of an RCT, were insufficient data for the standard of evidence-based guidelines defined by the Institute of Medicine (since renamed the National Academy of Medicine) 40

doi: 10.3390/healthcare9050494 189 MartinCROsadchiyVKalaniAMayerEA

Localized injections may still have a role in some situations, but healing is usually influenced by much more than simply placing a needle into the exact area of pain