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Most notably, any pharmacological intervention targeting AQP4 could affect functions as diverse as cell volume control, K + homeostasis and clearance of waste products including peptides associated with neurodegenerative disease

Some users find that starting with lower doses reduces nausea

All three would say their outcomes were real, not miraculous, which is about what the evidence predicts

Kanagal-Shamanna R, Montalban-Bravo G, Katsonis P, Sasaki K, Class CA, Jabbour E, Sallman D, Hunter AM, Benton C, Chien KS, Luthra R, Bueso-Ramos CE, Kadia T, Andreeff M, Komrokji RS, Al Ali NH, Short N, Daver N, Routbort MJ, Khoury JD, Patel K, Ganan-Gomez I, Wei Y, Borthakur G , Ravandi F, Do KA, Soltysiak KA, Lichtarge O, Medeiros LJ, Kantarjian H, Garcia-Manero G

doi: 10.1016/j.clim.2020.108630 285 CoxMAKahanSMZajacAJ

The leap from animal model findings to confirmed human benefit is significant, and many compounds that show promise in preclinical research do not translate successfully to human medicine