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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

But often, a hidden culprit is a vitamin B12 deficiency causing a specific type of anemia

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J Clin Endocrinol Metab 82 : 727734 Jorgensen JO et al

The remaining two LD/LD-V, two WD/LD-V, and three WD/LD-T mice were euthanized 2 days later