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Of important note, vitamin D may also be able to reduce excitotoxicity through its action on L-type calcium channels which are thought to modulate NMDA receptors (Hur et al., 2014), and to increase release of the anti-inflammatory cytokine, IL-10 (Selhub, 2002) to provide cysteine for the production of glutathione (Wu et al., 2004)

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IGF-1R expression in tumors has been shown to be positively correlated with the probability of recurrence after primary radiotherapy and is associated with adverse outcomes postradiotherapy in PCa [42]

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Molecular genetics and metabolism