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Mutations in the Golgi zinc transporter ZIP13 cause spondylocheirodysplastic EhlersDanlos syndrome (EDS), a connective-tissue disorder characterized by short stature, hyperextensible skin, joint laxity and skeletal abnormalities 34,35,116,138,139,140,141,142

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10.1128/MCB.26.1.221-229.2006 45 KobayashiM.ItohK.SuzukiT.OsanaiH.NishikawaK.KatohY.et al (2002)

This indirect mechanism ensures that even if only a small percentage of intact NAC reaches the systemic circulation, it still profoundly amplifies the amount of raw material available for cells to rebuild their glutathione reserves

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