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Nicotine increases the expression of kidney injury molecule-1, the classic epithelial-mesenchymal transition (EMT) markers, vimentin, fibronectin, and production of -smooth muscle actin (-SMA), TGF-, MCP-1, and ROS in the renal epithelium

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These withdrawal symptoms also overlap with other serious medical conditions, like malignant hyperthermia, serotonin syndrome, neuroleptic malignant syndrome, and thyrotoxicosis