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147,152,153 Among them, 11 C- and 18 F-labeled dihydrotetrabenazine (DTBZ) derivatives (structures not shown) have demonstrated promising results

Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, et al

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& Garcia-Tsao, G

Diabetologia 56: 1980-1986, 2013

These effects were coupled to an amelioration in lipid metabolism and hepatic steatosis, which markedly exceeded the effect of single GLP-1RA treatment ( Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively