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These pathways are particularly significant for macromolecules and surface-modified particulate systems, where ligand attachment or mucoadhesive coatings may enhance epithelial interaction and promote uptake, thereby increasing the likelihood of transport via olfactory and trigeminal neuronal pathways (Dhuria et al., 2010, Pardeshi and Belgamwar, 2013)

Evaluation of simvastatin as a disease-modifying treatment for patients with Parkinson disease: a randomized clinical trial

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Given what is known about aging, it has been suggested that integrated therapeutic alternatives should be explored to slow the aging rate in order to prevent or delay more efficiently, age-related diseases instead of treating them individually, which is the most common pharmacological approach currently used (Vaiserman et al., 2021)

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