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Consider breaks: Long-term use may require tolerance-prevention cycles

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions

Then his doctor started him on Mounjaro (tirzepatide)

I want to be able to keep up with them and to be around for their future she says

Practical Considerations: What to Expect Starting Tirzepatide Tirzepatide is started at 2.5 mg weekly and titrated upward every 4 weeks based on tolerability and response

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