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Although analyses suggest that inflammation and oxidative stress promote E3 ubiquitin ligase activity, the specific E3 ligase responsible for GPX4 ubiquitination, its target sites, and their actual changes in human OA tissues have not been clearly identified

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React Oxyg Species (Apex) (2016) 1:921

[Google Scholar] 44.Pop-Busui R., Ang L., Boulton A., Feldman E., Marcus R., Mizokami-Stout K., Singleton J.R., Ziegler D

biological effect studies on Semax showed that this peptide has pronounced nootropic, neuroprotective, and neurotrophic properties, 4650 stimulating learning and memory formation in rodents and humans

Oxidative stress in the CNS acts as a persistent inflammatory trigger by activating brain-resident immune cells, particularly microglia and astrocytes