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Gralczyk-Bikowska A, Szmajda-Krygier D, Kozowska E
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10.1016/j.copbio.2012.08.005 [DOI] [PubMed] [Google Scholar] McGuire S
Directing a jet of water forcefully onto the powder cake creates localised shear force that can mechanically disrupt peptide bonds this is one of the causes of poor reconstitution and reduced activity