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The latter option, that loss of oxidants can augment apoptosis, is supported by findings that correlate increased cellular hydrogen peroxide levels with resistance to apoptotic signaling in some cell systems (18, 86), as catalase overexpression in either cytoplasmic or mitochondrial compartments potentiated apoptosis, whereas inhibiting endogenous catalase promoted cell survival

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[DOI] [PMC free article] [PubMed] 24.Simpson SaP L