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Neurosci Biobehav Rev 24:3139 Sagvolden T, Pettersen MB, Larsen MC (1993) Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behaviour compared to four other rat strains

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Wu C, Ba Q, Lu D, Li W, Salovska B, Hou P, et al
This helps protect it from light and other things that could get in

Research supports: Reduced joint inflammation in arthritis models with daily use, showing long-term benefits up to one year
Notably, Th17 and Treg cells exhibit lineage plasticity under certain microenvironmental conditions, influenced by cytokines such as TGF-, IL-6, IL-23, and IL-10

To provide a more accurate prediction of skin irritancy potential of the test compound, in vitro skin irritation test can include other potential biomarkers
