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2020) While there have been improvements in cardiometabolic factors in response to GCGR activation such as body weight, steatohepatitis, and glucose homeostasis, there are concerns due to the potential impact of GCGR agonism on the heart

doi: 10.1093/clinids/19.6.1092 20 Navarro-FloresAFernandez-ChinguelJEPacheco-BarriosNSoriano-MorenoDRPacheco-BarriosK

doi: 10.1016/j.molmed.2009.06.007

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But the study has limitations since it relies on data from electronic health records

For anyone researching what 20 units means in milligrams , at 40 mg/mL concentration, 20 units delivers 8 mg of tirzepatide