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For example, Tonum reported Motus human clinical trial results of roughly 10.4% average weight loss over six months with preferential fat loss

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Similarly, a follow up study by the same group showed that plasmalogens containing arachidonic acid at the sn-2 position are reduced in the adipocyte membranes of morbidly obese twins compared to metabolically healthy twins (Pietilinen et al., 2011)

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Key Takeaways In general, it is best not to take creatine on an empty stomach since this could increase your likelihood of experiencing negative digestive symptoms such as nausea, stomach cramping, and diarrhea