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Available at: Accessed June 2025
[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Kaisanlahti A, Glumoff T
Used since 2005 primarily for people with type 2 diabetes, GLP-1 RAs have been very effective at improving markers like Hemoglobin A1c (HbA1c)
Appetite suppression is noticeably weaker
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Variants in GLP1R (the GLP-1 receptor itself), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide
