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These factors may determine abnormal signaling to neural circuits (intrinsic primary afferent nerves and extrinsic primary afferent nerves), which in turn may affect intestinal physiology and sensory perception (197)

Clinical data from LS patients also highlight marked gliosis as a characteristic finding, potentially resulting from reactive processes secondary to neuronal damage but it could be also a result of an increased propensity of NPCs to differentiate into astrocytes due to LS-causative mutations and mitochondrial dysregulation

This study also showed that GLP-1 and the GLP-1MK-801 conjugate promote enhanced whole-body lipid oxidation, evident by a decrease in respiratory exchange ratio (RER) compared with vehicle or MK-801 treatment (Extended Data Fig

Zhang B

Any injection-related adverse effects typically subside within one to three days following administration