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Nowadays, the vast majority of genes whose mutation lead to functional vitamin B 12 deficiency have been identified, and therefore, sequencing of these genes or next generation sequencing permits unequivocal diagnosis (Pupavac et al., 2016)

Lahmi A, Oryan S, Eidi A, Rohani AH

The same formula, the same nurse, the same outcome, without even having to leave home

The observed plasma increase in adenosine could be due to a decrease in adenosine deaminase activity, inhibition of adenosine kinase, or an increase in 5-nucleotidase, all of which can occur in the presence of oxidative stress [7072]

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It is important to understand that responses vary, and oral supplementation should be considered part of a broader strategy rather than a standalone solution