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At 8 months, the results were similar to those obtained at 15 weeks for mutants injected with Gsto2 -shRNA or scrambled shRNA (Fig

[DOI] [PubMed] [Google Scholar] 44.Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB

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Simultaneously, the activation of plaque macrophages by CD4 + T lymphocytes through CD40LCD40 signaling amplifies pro-inflammatory cytokine secretion, promotes macrophage polarization towards the M1 phenotype, and recruits immune cells, collectively perpetuating plaque instability