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Rohde, K

Alpha-Lipoic Acid Protects against Pressure Overload-Induced Heart Failure via ALDH2-Dependent Nrf1-FUNDC1 Signaling

doi: 10.1038/s41467-017-01019-z 12 ZhaoWWangYLiuJYangQZhangSHuXet al

c , As in b , but showing another held-out metabolite, isatin

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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]