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Archived from the original (PDF) on 6 October 2014

Notably, the origin and fate of acetyl-CoA are key factors that help distinguish between M1 and M2 ( Figure 1 Figure 2 In a nutshell, pro-inflammatory M1 macrophages are metabolically characterized by a high reliance on aerobic glycolysis and present two key breaks in the TCA cycle, leading to the accumulation of citrate, succinate, and itaconate

References 1 MameliCGuadagniLOrsoMCalcaterraVWasniewskaMGAversaTet al
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15 Of note, no medical device should be advertised as FDA approved or cleared. This is considered misbranding by the FDA under section 21 CFR 807.97
