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Concomitantly, aging induces characteristic morphological changes in notochordal NP cells, including increased cell area, diameter, and vesicle content [46], and diminishes NPPC pluripotency, characterized by decreased expression of core pluripotency markers like POU5F1 (also known as OCT4) and NANOG (Fig

Alhallak K, Sun J, Jeske A, et al

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