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Discovered in 1876 by Heinrich Caro, methylene blue holds the distinction of being the first fully synthetic drug, marking a significant milestone in the history of pharmaceuticals

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The effects of NAC or L-NAC against PQ-induced cytotoxicity in A549 cells were assessed by measuring cellular PQ uptake, intracellular glutathione content, ROS levels, mitochondrial membrane potential, cellular gene expression, inflammatory cytokine release and cell viability

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Alongside this, other symptoms can include: As the cause of burning mouth syndrome is unknown, diagnosis and treatment can be difficult

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