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Loss or gain of function in DWF or BZR1 disrupted ROS production and PCD timing in tapetal cells, resulting in delayed or premature degeneration (Yan et al., 2020)

(133) administered DF at different levels for 8 weeks in an SD rat model of osteoarthritis, and 16S rRNA sequencing showed that high DF intake significantly increased the abundance of Bacillota-dominant microbiota and attenuated the extent of osteoarthritic lesions

The compound has not completed Phase I, II, or III evaluation under any regulatory framework

Other ergot derivatives are used as prolactin inhibitors, in the treatment of Parkinsonism, and in cases of cerebrovascular insufficiency [149]

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Of note, maca is also not a phytoestrogen with high concentrations of isoflavones like soybean and red clover [27,135,152], but it has been proposed to have progestin-like activity due to increases in uterine weight seen in a study with ovariectomized mice [164]