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Materials and Methods Fly stocks The following flies were used in this study: w 1118 (NO.5905), UAS- dicer (NO

Ultra-flexible liposomes Ultra-flexible liposomes such as transferosomes, ethosomes, and transethosomes possess high elasticity, enabling them to penetrate skin layers easily and deliver drugs to the desired site without any drug loss, enhancing bioavailability and therapeutic efficacy while decreasing their side effects [125]

Melatonin also potentiates the function of the mitochondrial electron transport chain, which reduces free radical generation and electron leakage (316)

Glycine is an amino acid and acts as a fundamental building block for the proteins within the human body

In contrast, treatment with DL-propargylglycine (PAG), a CSE inhibitor, exacerbated T2DM-induced liver injury, leading to severe hepatocellular vacuolation, heightened oxidative stress, and amplified inflammation [76]