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However, treatment decisions must consider intracerebral hemorrhage risk, especially in patients with extensive cerebral microbleeds or CAA

At the cellular level, the structural and functional dysfunction of endothelium is due to the lack of nitric oxide (NO), cellular oxidative stress, the inflammatory process, and a damaged glycocalyx structure
The reason for choosing these three polymers for microneedles preparation is to obtain microneedles with good biocompatibility, appropriate dissolution rate and mechanical strength [[37], [38], [39]]

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