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Description
A second binding cavity, the H-site, is formed by three regions of the primary structure: 1) in the N-terminus contributions from residues 10,12 and the methylene groups of Arg13, Gly14, and Arg15

Thanks to the activation of the TLR4 pathway, Ikb- is phosphorylated and degraded by proteasome, leading to NFkB release and translocation into the nucleus to increase the expression of targeting genes implicated in the inflammatory response [36,37]

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