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The increased oxidative environment resulting from NOX activity and mtROS production leads to GSH depletion
Kovik A
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10.1093/aje/kww177 Am
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Interestingly, GSTO1 was identified as one of the potential cellular targets of piperlongumine, an electrophilic compound exerting selective cytotoxicity against cancer cells through an oxidative cell death mechanism (Supplementary Table 25) 37
