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After skin damage, the newly growing epidermis and skin cells at the wound edge express more metallothionein than does the surrounding normal skin

This phenomenon is predominantly attributable to reciprocal fluctuations in thermogenesis and expenditure, accompanied by a substantial augmentation in cold-seeking behaviors (Tan et al., 2016)

doi: 10.1046/j.1439-0272.2003.00564.x 36 AitkenRPatersonMFisherHBuckinghamDVan DuinM

Furthermore, AMPs frequently demonstrate suboptimal pharmacokinetic properties, such as rapid systemic clearance and limited bioavailability, necessitating the development of advanced delivery systems to enhance their efficacy [181]

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