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In relation to the bone, IGF-1 is an important mediator of the effects of GH and modulates bone growth through its paracrine action in the growth plate (220) as it was demonstrated that the selective deletion of the igf1 gene in the liver and a consequent decrease in systemic IGF-1 did not affect the animals body and femoral growth (221)

Research confirms that Pycnogenol enhances endothelial NO production by increasing endothelial nitric oxide synthase (eNOS) activity and protects the generated NO from degradation by scavenging superoxide anion radicals, thereby improving its bioavailability (250)

It supports your bodys natural repair systems and may help slow the biological clock from the inside out

STUDY SOURCE: tinyurl.com/IceWaveStudy The Silent Nights patch is clinically proven to increase serotonin levels to promote melatonin in low light

Vollmar and Menger, 2011)

it reflects real neurobiological changes in pain processing circuits that take time to normalize