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Once released by ferroptotic cells, these extracellular DAMPs bind to the receptor advanced glycosylation end-product specific receptor (AGER) on macrophages and trigger either proinflammatory cytokine production in a nuclear factor-B (NF-B)-dependent manner or macrophage polarization-associated tumor progression ( Figure1 )
Lipoic acid exists in two forms: R-lipoic acid and S-lipoic acid
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They also had an elevated expression of integrin beta 1 [37,38]
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