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It stimulates VEGF to promote new blood vessel growth, enhances growth hormone receptor expression, and upregulates pro-repair signaling cascades

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Topical application is limited by the stratum corneum barrier, with near-zero penetration through intact skin (Li et al., 2015)

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Instead, you begin low and increase gradually over weeks, giving your body time to adjust and minimizing the gastrointestinal side effects that come with GLP-1 receptor activation