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The model used is a clinically relevant model of post-ischemic reperfusion damage, which following recent advances in reperfusion therapies (thrombolysis combined with mechanical thrombectomy) has gained clinical importance

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and this uptake was suppressed by i.v

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Es wurde das von der Lys- und der Asp-Schutzgruppe befreite Peptidharz in einem geeigneten Lsungsmittel wie DMF, Dichlormethan (DCM) oder 1-Methyl-2-pyrrolidon (NMP) suspendiert, ein geeignetes cyclisches Kopplungsmittel wie 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluroniumtetrafluorborat (TBTU), 2-(7-Aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluroniumtetrafluorborat (TATU), 2-(2-Oxo-1(2H)-pyridyl)-1,1,3,3-tetramethyluroniumtetrafluorborat (TPTU) oder N,N'-Dicyclohexylcarbodiimid-1-hydroxybenzotriazol (DCCI/HOBt) hinzugegeben und die Kopplung durch Einsatz einer geeigneten Base wie N,N-Diisopropylethylamin (DIPEA), Sym-Collidin oder N-Methylmorpholin (NMM) ausgelst