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These hydroxyl radicals then react with membrane PUFAs, generating lipid radicals that initiate lipid oxidation ( 2.2 Lipid peroxidation in ferroptosis Due to the weak double bonds present in polyunsaturated fatty acids (PUFAs), hydrogen atoms are more easily abstracted from PUFAs than from saturated or monounsaturated fatty acids

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doi: 10.1016/j.mce.2016.09.028, [DOI] [PubMed] [Google Scholar] Karagiannis A., Gallopin T., Lacroix A., Plaisier F., Piquet J., Geoffroy H., et al