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The mutual outcome of these two effects is the upregulation of hepatic BA formation and emission of conjugated BAs into the blood circulation, which distally anchors the FXR in the bone marrow, resulting in the loss of osteoblast function, negatively impacting BMD, bone volume fraction, and fracture resistance (115)

GSTA2X was a crucial isoform and we further expressed it using Pichia pastoris X-33 and determined its enzymatic characteristics and kinetic parameters

Steps toward understanding mitochondrial Fe/S cluster biogenesis

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Collectively, these studies will provide a clearer theoretical framework and translational basis for the precise application of butyrate in OA

doi: 10.1021/jf0209894