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doi: 10.1079/9781780642635.0390 13 BackK

[DOI] [PMC free article] [PubMed] [Google Scholar] 226.Xu S., Han X., Wang X., Yu Y., Qu C., Liu X., Yang B
There are currently no approved cancer therapies for this indication

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The absolute oral bioavailability of silybin in humans is strikingly low (~0.45 0.28%), attributable to multiple interrelated factors, including poor aqueous solubility, limited membrane permeability, active intestinal efflux, extensive first-pass hepatic metabolism, and accelerated biliary excretion (Figure 3) [33]
& Li, B
