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Description
This reaction depends on the catalytic selenocysteine residue of GPX4, which is directly targeted and inactivated by ferroptosis inducers such as RSL3
The short TM4 sequence C P C is characteristic of both P 1B-1 and P 1B-2 transporters, widely accepted to transport Cu I and Zn II /Cd II /Pb II , respectively, but each differs on the basis of residues in TM6 (Figure 56)

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