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Lactate regulates T-cell differentiation, a process critical for sustaining chronic inflammation

Su et al., 2023

FEBS Lett 529:93101 Taylor JM, Ali U, Iannello RC, Hertzog P, Crack PJ (2005) Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death

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Another significant obstacle is the permeability of the bloodbrain barrier, as many small compounds that demonstrate strong in vitro efficacy have limited exposure to the central nervous system (CNS) in vivo, necessitating high doses that may increase systemic toxicity