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Glutathione levels decline due to increased oxidative stress, reduced synthesis capacity, mitochondrial dysfunction, chronic inflammation, and depletion of essential nutrients required for its production

When TLR4 was inhibited in mice, enhanced NF-B pathway, and augmented atherosclerotic plaque loads were diminished (19)

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Furthermore, in vivo experiments revealed its suppressive effects on tumor growth and invasion in HCT116 xenograft nude mouse models