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Collagen synthesis (types I and III) increased significantly, along with improvements in elastin and glycosaminoglycan production (Pickart et al., 2018)

Dermal thickness, defined as the distance from the epidermaldermal junction to the dermaladipose junction or to the loose connective tissue subjacent to the panniculus carnosus, respectively, were determined at five randomly selected sites per h.p.f., as previously described 65