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Tauroursodeoxycholate (TUDCA), which is a member of the ERS inhibitor, can reduce IH-induced neuronal apoptosis in the hippocampal CA1 region by upregulating the anti-apoptotic protein Bcl-2 in mice [46]
doi:10.1039/c2ib00155a Chandrasekaran K, Swaminathan K, Mathan Kumar S, Clemens DL, Dey A (2012) In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity
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Therefore, current observational findings should primarily be considered hypothesis-generating, and robust interventional studies are needed before firm clinical recommendations can be made [92, 122]
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No association of glutathione S-transferase M1 gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic patients
