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During metabolism most drugs lose the pharmacological activity and are excreted from the body

This Research Topic is part of a series with:The changing faces of glutathione, a cellular protagonist., Volume IIGlutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases

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High glutamine-induced mTORC1 hyperactivation resulted in the suppression of mTORC2, which otherwise stabilizes RUNX2 via GSK3 inhibition through pAKT-473
