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doi: 10.1038/s41583-022-00564-x 276 TokudaE.FurukawaY

Nearer-Term Availability# Recommendation : CagriSema Reason : NDA filed with FDA based on completed Phase 3 REDEFINE program

The weight loss and metabolic improvements dramatically reduce cardiovascular risk, far outweighing any heart rate concern

GLP-1 Receptor Agonists May Modestly Reduce Risk of Fourteen Obesity-Related Cancers for People with Diabetes

By influencing gene expression, collagen production, and regenerative pathways, it may support deeper and more lasting improvements in skin health

It is suggested that the reverse cholesterol transport system played a significant role in atherosclerosis progression, stimulating the cholesterol movement from the peripheral tissues to the liver for re-use or excretion into the bile acid and by upregulating cytochrome P450 7A1 (81)