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with 20 being upregulated and 36 repressed in the presence of YE (Table 2)

Another limitation is the diversity of populations, as the studies do not focus on a single, specific population but rather exhibit a broad range of demographic characteristics

Nrf2 is then free to translocate into the nucleus and induce the transcription of phase 2 detoxification enzyme genes (2)

Similarly, DMT1 is not essential for Mn uptake across the BBB

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These malignant effects are ultimately caused by unregulated oxygen- and nitrogen-containing free radicals that attack different cells and damage DNA, proteins, and lipids