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1 Introduction Cardiovascular disease (CVD) is the leading cause of morbidity and mortality, affecting over 523 million people globally, and CVD mortality rates are predominated by atherosclerotic diseases (Zhou and Wu, 2023)

Activation of inflammatory vesicles in microglia by -synucleinogen fibers occurs early in the development of PD, leading to an inflammatory cascade and MGC proliferation

Emerging evidence indicates that exercise can suppress ferroptosis directly or indirectly by regulating iron metabolism, oxidative stress, and exerkine expression, thereby conferring neuroprotection

doi: 10.1007/s11910-023-01282-2 196

They can be transported by the circulatory system toward distance targets (e.g., tissues, organs), determining an increase or decrease of cellular activities

Engelmann, H., Aderka, D., Rubinstein, M., Rotman, D