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"ASCO guideline: chemotherapy-induced peripheral neuropathy." J Clin Oncol 2020;38(28):3325-48

Youre taking any medications for diabetes for insulin control, since this can raise the risk for hypoglycemia and low blood sugar

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Other side effects, like nausea or diarrhea, are uncommon at standard doses (500-2000 mg)

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(Also check COMT possible interaction with slow COMT) Hesperidin (PTPN22 variant, TNF variant): A natural flavonoid from citrus fruits, hesperidin, inhibits the release of TNF-alpha.[ref][ref] Related article: Read more about hesperidin